Chronic Experimental Hypertension in Dogs after Constriction of Brachiocephalic and Left Subclavian Arteries

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Chronic experimental hypertension in dogs after constriction of brachicephalic and left subclavian arteries.

• Chronic hypertension of moderate to marked severity has been produced in dogs by bilateral carotid sinus area constriction with specially devised plastic clamps.' 3 Three possible mechanisms have been proposed to explain this type of experimental hypertension: (a) an alteration in cerebral hemodynamics, presumably leading to the liberation of an increase in total peripheral resistance;'' (b) ...

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When Goldblatt and coworkers (1) in 1934 first announced that a significant and sustained elevation in arterial blood pressure could be produced in dogs by constriction of the renal arteries they also reported a few experiments in which the level of the guanidine bases in the blood stream of these animals had been followed. Although their preliminary studies indicated that these substances were...

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Pathogenesis of experimental hypertension produced by carotid sinus area constriction in dogs.

IN .1954 our research group reported that modest to high level, persistent hypertensions could be produced in dogs by bilateral constriction of the carotid sinus area by means of a plastic clamp which reduced the volume pulse of the sinus and the internal carotid, occipital, and external carotid arteries to approximately one third normal. This report suggested that the hypertension was probably...

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Pathogenesis of Experimental Hypertension Produced by Carotid Sinus Area Constriction in Dogs

IN .1954 our research group reported that modest to high level, persistent hypertensions could be produced in dogs by bilateral constriction of the carotid sinus area by means of a plastic clamp which reduced the volume pulse of the sinus and the internal carotid, occipital, and external carotid arteries to approximately one third normal. This report suggested that the hypertension was probably...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1962

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.11.1.153